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Journal Articles: 1975-1989 | 1990-1999 | 2000-2009 | 2010-2015 | 2016-
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JOURNAL ARTICLES

2016- return to top

Mishanina TV, Palo MZ, Nayak D, Mooney RA, Landick R. 2017. Trigger loop of RNA polymerase is a positional, not acid-base, catalyst for both transcription and proofreading. Epub ahead of print (incl. supplement)

Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R, Darst SA. 2017. RNA polymerase motions during promoter melting. Science., 356, 863-866. (incl. supplement; Movie S1)

Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Fürtig B, Wöhnert J, Schwalbe H. 2017. Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation. Elife., 6, e21297. (incl. supplement)

Tetone LE, Friedman LJ, Osborne ML, Ravi H, Kyzer S, Stumper SK, Mooney RA, Landick R, Gelles J. 2017. Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proc. Natl. Acad. Sci. U. S. A., 114, E1081-E1090. (incl. supplement)

Sato TK, Tremaine M, Parreiras LS, Hebert AS, Myers KS, Higbee AJ, Sardi M, McIlwain SJ, Ong IM, Breuer RJ, Narasimhan RA, McGee MA, Dickinson Q, La Reau A, Xie D, Tian M, Piotrowski JS, Reed JL, Zhang Y, Coon JJ, Hittinger CT, Gasch AP, Landick R. 2016. Directed evolution reveals unexpected epistatic interactions that alter metabolic regulation and enable anaerobic xylose use by Saccharomyces cerevisiae. PLoS Genet., 12, e1006372. (incl. supplement and erratum, published in PLoS Genet., 12, e1006447.)

Ghosh IN, Landick R. 2016. OptSSeq: High-throughput sequencing readout of growth enrichment defines optimal gene expression elements for homoethanologenesis. ACS Synth. Biol., 5, 1519-1534. (incl. supplement)

McIlwain SJ, Peris D, Sardi M, Moskvin OV, Zhan F, Myers K, Riley NM, Buzzell A, Parreiras LS, Ong IM, Landick R, Coon JJ, Gasch AP, Sato TK, Hittinger CT. 2016. Genome sequence and analysis of a stress-tolerant, wild-derived strain of Saccharomyces cerevisiae used in biofuels research. G3 (Bethesda)., 6, 1757-1766. (incl. supplement; supplemental tables)

Ray-Soni A, Bellecourt MJ, Landick R. 2016. Mechanisms of bacterial transcription termination: all good things must end. Annu. Rev. Biochem., 85, 319-347.

Zhang J, Landick R. 2016. A two-way street: regulatory interplay between RNA polymerase and nascent RNA structure. Trends Biochem. Sci. 41, 293–310.

Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS. 2016. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain. Microb. Cell Fact. 15, 17.

Ronayne EA, Wan YC, Boudreau BA, Landick R, Cox MM. 2016. P1 ref endonuclease: a molecular mechanism for phage-enhanced antibiotic lethality. PLoS Genet. 12, e1005797.

Harden TT, Wells CD, Friedman LJ, Landick R, Hochschild A, Kondev J, Gelles J. 2016. Bacterial RNA polymerase can retain sigma70 throughout transcription. Proc. Natl. Acad. Sci. U. S. A. 113, 602-607. (incl. supplement)


2010-2015 return to top

Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y. 2015. Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation. Biotechnol. Biofuels. 8, 180.

Bae B, Feklistov A, Lass-Napiorkowska A, Landick R, Darst SA. 2015. Structure of a bacterial RNA polymerase holoenzyme open promoter complex. eLife 4, e08504. (incl. supplement)

Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y. 2015. Plant-derived antifungal agent poacic acid targets beta-1,3-glucan. Proc. Natl. Acad. Sci. U. S. A. 112, E1490-1497. (incl. supplement)

Bae B, Nayak D, Ray A, Mustaev A, Landick R, Darst SA. 2015. CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc. Natl. Acad. Sci. U. S. A. 112, E4178-E4187. (incl. supplement)

Kotlajich MV, Hron DR, Boudreau BA, Sun Z, Lyubchenko YL, Landick R. 2015. Bridged filaments of histone-like nucleoid structuring protein pause RNA polymerase and aid termination in bacteria. eLife. 4, e04970.

Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R. 2014. Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase. Nucleic Acids Res. 42, 12707-12721. (incl. supplement)

Hein PP, Kolb KE, Windgassen T, Bellecourt MJ, Darst SA, Mooney RA, Landick R. 2014. RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movement. Nat. Struct. Mol. Biol. 21, 794-802. (incl. supplement)

Haft RJ, Keating DH, Schwaegler T, Schwalbach MS, Vinokur J, Tremaine M, Peters JM, Kotlajich MV, Pohlmann EL, Ong IM, Grass JA, Kiley PJ, Landick R. 2014. Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria. Proc. Natl. Acad. Sci. U. S. A. 111, E2576-E2585. (incl. supplement)

Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. 2014. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 344, 1042-1047. (incl. supplement)

Czyz A, Mooney RA, Iaconi A, Landick R. 2014. Mycobacterial RNA polymerase requires a U-tract at intrinsic terminators and is aided by NusG at suboptimal terminators. MBio. 5, e00931. (incl. supplement)

Zhang Y, Mooney RA, Grass JA, Sivaramakrishnan P, Herman C, Landick R, Wang JD. 2014. DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest. Mol. Cell. 53, 766-778. (incl. supplement)

Kolb KE, Hein PP, Landick R. 2014. Antisense oligonucleotide-stimulated transcriptional pausing reveals RNA exit channel specificity of RNA polymerase and mechanistic contributions of NusA and RfaH. J. Biol. Chem. 289, 1151-1163.

Nayak D, Voss M, Windgassen T, Mooney RA, Landick R. 2013. Cys-pair reporters detect a constrained trigger loop in a paused RNA polymerase. Mol. Cell. 50, 882-893. (incl. supplement)

Mooney RA, Landick R. 2013. Building a better stop sign: understanding the signals that terminate transcription. Nat. Methods. 10, 618-619.

Weixlbaumer A, Leon K, Landick R, Darst SA. 2013. Structural basis of transcriptional pausing in bacteria. Cell. 152, 431-441. (supplemental movie)

Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA. 2013. Structure and function of CarD, an essential mycobacterial transcription factor. Proc. Natl. Acad. Sci. U. S. A. 110, 12619-12624. (incl. supplement)

Chung D, Park D, Myers K, Grass JA, Kiley P, Landick R, Keles S. 2013. dPeak: high resolution identification of transcription factor binding sites from PET and SET ChIP-seq data. PLoS Comput. Biol. 9, e1003246.

Park DM, Akhtar MS, Ansari AZ, Landick R, Kiley PJ. 2013. The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally. PLoS Genet. 9, e1003839.

Myers KS, Yan H, Ong IM, Chung D, Liang K, Tran F, Keles S, Landick R, Kiley PJ. 2013. Genome-scale analysis of Escherichia coli FNR reveals complex features of transcription factor binding. PLoS Genet. 9, e1003565.

Decanio MS, Landick R, Haft RJ. 2013. The non-pathogenic Escherichia coli strain W secretes SslE via the virulence-associated type II secretion system beta. BMC Microbiol. 13, 130. (plasmid sequences)

Peters JM, Mooney RA, Grass JA, Jessen ED, Tran F, Landick R. 2012. Rho and NusG suppress pervasive antisense transcription in Escherichia coli. Genes Dev. 26, 2621-2633. (supplemental tables)

Koslover DJ, Fazal FM, Mooney RA, Landick R, Block SM. 2012. Binding and translocation of termination factor Rho studied at the single-molecule level. J. Mol. Biol. 423, 664-676. (incl. supplement)

Burmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, Rosch P. 2012. An alpha-helix to beta-barrel domain switch transforms the transcription factor RfaH into a translation factor. Cell 150, 291-303.

Palangat M, Larson M, Hu X, Gnatt A, Block S, Landick R. 2012. Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription 3, 146-153.

Larson MH, Zhou J, Kaplan CD, Palangat M, Kornberg RD, Landick R, Block SM. 2012. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc. Natl. Acad. Sci. U. S. A. 109, 6555-6560. (incl. supplement)

Schwalbach MS, Keating DH, Tremaine M, Marner WD, Zhang Y, Bothfeld W, Higbee A, Grass JA, Cotten C, Reed JL, da Costa Sousa L, Jin M, Balan V, Ellinger J, Dale B, Kiley PJ, Landick R. 2012. Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen. Appl. Environ. Microbiol. 78, 3442-3457. (supplemental information)

Palangat M, Grass JA, Langelier MF, Coulombe B, Landick R. 2011. The RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation. Mol. Cell Biol. 31, 3312. (incl. supplement)

Hein PP, Palangat M, Landick R. 2011. RNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase. Biochemistry. 50, 7002. (incl. supplement)

Sevostyanova A, Belogurov GA, Mooney RA, Landick R, Artsimovitch I. 2011. The beta subunit gate loop is required for RNA polymerase modification by RfaH and NusG. Mol. Cell 43, 253-26. (incl. supplement)

Peters JM, Vangeloff AD, Landick R. 2011. Bacterial transcription terminators: the RNA 3'-end chronicles. L. Mol. Biol. 412, 793-813.

Hein PP, Landick R. 2010. The bridge helix coordinates movements of modules in RNA polymerase.. BMC Biol. 8, 141.

Conrad TM, Frazier M, Joyce AR, Cho BK, Knight EM, Lewis NE, Landick R, Palsson BO. 2010. RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media. Proc. Natl. Acad. Sci. U. S. A. 107, 20500-20505. (incl. supplement)

Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA. 2010. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS Biol. 8, e1000483.

Ha KS, Toulokhonov I, Vassylyev DG, Landick R. 2010. The NusA N-terminal domain is necessary and sufficient for enhancement of transcriptional pausing via interaction with the RNA exit channel of RNA polymerase. J. Mol. Biol. 401, 708-725. (incl. supplement)

Herbert KM, Zhou J, Mooney RA, Porta AL, Landick R, Block SM. 2010. E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J. Mol. Biol. 399, 17-30.

Zhang J, Palangat M, Landick R. 2010. Role of the RNA polymerase trigger loop in catalysis and pausing. Nat. Struct. Mol. Biol., 17, 99-104. (incl. supplement)


2000-2009 return to top

Peters JM, Mooney RA, Kuan PF, Rowland JL, Keles S, Landick R. 2009. Rho directs widespread termination of intragenic and stable RNA transcription. Proc. Natl. Acad. Sci. U. S. A. 106, 15406-15411. (supplemental datasets)

Mooney RA, Schweimer K, Rösch P, Gottesman M, Landick R. 2009. Two structurally independent domains of E. coli NusG create regulatory plasticity via distinct interactions with RNA polymerase and regulators. J. Mol. Biol. 391, 341-358. (incl. supplement)

Landick R. 2009. Transcriptional pausing without backtracking. Proc. Natl. Acad. Sci. U. S. A. 106, 8797-8798.

Landick R. 2009. Functional divergence in the growing family of RNA polymerases. Structure. 17, 323-325.

Mooney RA, Davis SE, Peters JM, Rowland JL, Ansari AZ, Landick R. 2009. Regulator trafficking on bacterial transcription units. Mol. Cell. 33, 97-108. (incl. supplement)

Belogurov GA, Mooney RA, Svetlov V, Landick R, Artsimovitch I. 2009. Functional specialization of transcription elongation factors. EMBO J. 28, 112-122. (incl. supplement)

Dufour Y, Landick R, Donohue T. 2008. Organization and evolution of the biological response to singlet oxygen stress. J. Mol. Biol. 383, 713-73. (incl. supplement)

Larson MH, Greenleaf WJ, Landick R, Block SM. 2008. Applied force reveals mechanistic and energetic details of transcription termination. Cell, 132,971-982. (audio interview)

Toulokhonov I, Zhang J, Palangat M, Landick R. 2007. A central role of the RNA polymerase trigger loop in active-site rearrangement during transcriptional pausing. Mol. Cell 27, 406-419. (incl. supplement)

Vassylyev DG, Vassylyeva MN, Zhang J, Palangat M, Artsimovitch I, Landick R. 2007. Structural basis for substrate loading in bacterial RNA polymerase. Nature.448, 163-168. (incl. supplement)

Kyzer S, Ha K, Landick R, Palangat M. 2007. Direct versus limited-step reconstitution reveals key features of an RNA hairpin-stabilized paused transcription complex. J. Biol. Chem. 282, 19020-19028.

Davis CA, Bingman CA, Landick R, Record MT Jr, Saecker RM. 2007. Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 104, 7833-7388. (incl. supplement)

Landick R. 2006. A long time in the making--the Nobel Prize for RNA polymerase. Cell. 127, 1087-1090.

Toulokhonov I, Landick R. 2006. The role of the lid element in transcription by E. coli RNA polymerase. J. Mol. Biol. 361, 644-658.

Dalal RV, Larson MH, Neuman KC, Gelles J, Landick R, Block SM. 2006. Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing. Mol. Cell. 23, 231-239. (incl. supplement)

Herbert KM, La Porta A, Wong BJ, Mooney RA, Neuman KC, Landick R, Block SM. 2006. Sequence-resolved detection of pausing by single RNA polymerase molecules. Cell. 125, 1083-1094. (incl. supplement)

Ederth J, Mooney RA, Isaakson L, Landick R. 2006. Functional interplay between the jaw domain of bacterial RNA polymerase and allele-specific residues in the product RNA-binding pocket. J. Mol. Biol. 365, 1163-1179.

Mooney RA, Darst SA, Landick R. 2005. Sigma and RNA polymerase: an on-again, off-again relationship? Mol. Cell. 20, 335-345.

Abbondanzieri EA, Greenleaf WJ, Shaevitz JW, Landick R, Block SM. 2005. Direct observation of base-pair stepping by RNA polymerase. Nature. 438, 460-465. (incl. supplement)

Palangat M, Renner DB, Price DH, Landick R. 2005. DSIF/NELF, a negative elongation factor for human RNA polymerase II, is a potent inhibitor of the anti-arrest factor TFIIS. Proc. Natl. Acad. Sci. U. S. A. 102, 315036-15042. (incl. supplement)

Herring CD, Raffaelle M, Allen TE, Kanin EJ, Landick R, Ansari AZ, Palsson BO. 2005. Immobilization of Escherichia coli RNA polymerase and location of binding sites by use of chromatin immunoprecipitation and microarrays. J. Bacteriol. 187, 6166-6174. (supplemental information)

Kyzer S, Zhang J, Landick R. 2005. Inhibition of RNA polymerase by streptolydigin: no cycling allowed. Cell. 122, 494-496.

Geszvain KM, Landick R. 2005. The structure of bacterial RNA polymerase. University of Wisconsin Dept. of Bacteriology. Web Site Edition, 12 pp.

Palangat M, Hittinger CT, Landick R. 2004. Downstream DNA selectively affects a paused conformation of human RNA polymerase II. J. Mol. Biol. 341, 429-441.

Artsimovitch I, Chu C, Lynch S, Landick R. 2003. A new class of bacterial RNA polymerase inhibitor affects nucleotide addition. Science 302, 650-654. (incl. supplement)

Mooney RA, Landick R. 2003. Tethering sigma70 to RNA polymerase reveals high in vivo activity of sigma factors and sigma70-dependent pausing at promoter-distal location. Genes Dev. 17, 2839-2851. (incl. supplement)

Toulokhonov I, Landick R. 2003. The flap domain is required for pause RNA hairpin inhibition of catalysis by RNA polymerase and can modulate intrinsic termination. Mol. Cell 12, 1125-1136. (incl. supplement)

Tolic-Norrelykke SF, Engh AM, Landick R, Gelles J. 2004. Diversity in the rates of transcript elongation by single RNA polymerase molecules. J. Biol. Chem. 279, 3292-3299. (incl. supplement)

Shaevitz JW, Abbondanzieri EA, Landick R, Block SM. 2003. Backtracking by single RNA polymerase molecules observed at near-base-pair resolution. Nature. 426, 684-687. (incl. supplement)

Neuman K, Abbondanzieri EA, Landick R, Gelles J, Block SM. 2003. Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell. 115, 437-447. (incl. supplement)

Wilson KA, Kalkum M, Ottesen J, Yuzunkova J, Chait BT, Landick R, Muir T, Severinov K, Darst SA. 2003. The structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail. J. Am. Chem. Soc. 125, 12475-12483. (incl. supplement)

Santangelo T, Mooney RA, Landick R, Roberts JW. 2003. RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins. Genes Dev 17, 1281-1292.

Artsimovitch I, Svetlov V, Murakami KS, Landick R. 2003. Co-overexpression of E. coli RNA polymerase subunits allows isolation and analysis of mutant enzymes lacking lineage-specific sequence insertions. J. Biol. Chem. 278, 12344-12355.

Yuzenkova J, Delgado M, Nechaev S, Savalia D, Epshtein V, Artsimovitch I, Mooney RA, Landick R, Farrias RN, Salomon R, Severinov K. 2002. Mutations of bacterial RNA polymerase leading to resistance to microcin j25. J. Biol. Chem. 277, 50867-50875.

Ederth J, Artsimovitch I, Isaksson L, Landick R. 2002. The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing. J. Biol. Chem. 277, 37456-37463.

Artsimovitch I, Landick R. 2002. The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand. Cell. 109, 193-203. Erratum in Cell. 2002 Sep 20; 110, 801.

Palangat M, Landick R. 2001. Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in nonequilibrium pausing by human RNA polymerase II. J. Mol. Biol. 311, 265-282.

Gruber TM, D. Markov D, Sharp MM, Young BA, Lui CZ, Zhong HJ, Artsimovitch I, Geszvain KM, Landick R, Severinov K, Gross CA. 2001. Binding of the initiation factor sigma70 to core RNA polymerase is a multistep process. Mol. Cell. 8, 21-31.

Toulokhonov I, Artsimovitch I, Landick R. 2001. Allosteric control of RNA polymerase by an interaction site for nascent RNA hairpins. Science. 292, 730-733.

Artsimovitch I, Svetlov V, Anthony L, Burgess RR, Landick R. 2000. RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro. J Bacteriol. 182, 6027-6035. Erratum in J. Bacteriol. 2001 Feb; 183, 1504.

Anthony LC, Artsimovitch I, Svetlov V, Landick R, Burgess RR. 2000. Rapid purification of His(6)-tagged Bacillus subtilis core RNA polymerase. Protein Expr. Purif. 19, 350-354.

Artsimovitch I, Landick R. 2000. Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals. Proc. Natl. Acad. Sci. U. S. A. 13, 7090-7095.

Davenport RJ, Wuite GJL, Landick R, Bustamante C. 2000. Single molecule study of transcriptional pausing and arrest by E. coli RNA polymerase. Science. 287, 2497-2500.

Opalka N, Mooney RA, Richter C, Severinov K, Landick R, Darst SA. 2000. Direct localization of a beta subunit domain on the three-dimensional structure of Escherichia coli RNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 97, 617-622.


1990-1999 return to top

Yin H, Artsimovitch I, Landick R, Gelles J. 1999. Non-equilibrium mechanism of transcription termination from observations of single RNA polymerase molecules. Proc. Natl. Acad. Sci. U. S. A. 96, 13124-13129.

Keene RG, Mueller A, Landick R, London L. 1999. Transcriptional pause, arrest, and termination sites for RNA polymerase II in mammalian N- and c-myc genes. Nucleic Acids Res. 27, 3173-3182.

Pan T, Artsimovitch I, Landick R, Sosnick T. 1999. Folding of a large ribozyme during transcription and the effect of the elongation factor NusA. Proc. Natl. Acad. Sci. U. S. A. 96, 9545-9550.

Wang MD, Schnitzer MJ, Yin H, Landick R, Gelles J, Block SM. 1998. Force and velocity measured for single molecules of RNA polymerase. Science. 282, 902-907.

Artsimovitch I, Landick R. 1998. Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release. Genes Dev. 12, 3110-3122.

Palangat M, Meier TI, Keene RG, Landick R. 1998. Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure. Mol. Cell. 1, 1033-1042.

Severinov K, Mooney RA, Darst SA, Landick R. 1997. Tethering of the large subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 272, 24137-24140.

Wang D, Severinov K, Landick R. 1997. Preferential interaction of the his pause RNA hairpin with RNA polymerase beta subunit residues 904-950 correlates with strong transcriptional pausing. Proc. Natl. Acad. Sci. U. S. A. 94, 8433-8438.

Wang M, Yin H, Landick R, Gelles J, Block SM. 1997. Stretching DNA with optical tweezers. Biophys. J. 72, 1335-1346.

Chan CL, Wang D, Landick R. 1997. Multiple interactions stabilize a single paused transcription intermediate in which hairpin to 3' end spacing distinguishes pause and termination pathways. J. Mol. Biol. 268, 54-68.

Chan CL, Landick R. 1997. Effects of neutral salts on transcript elongation and pausing. J. Mol. Biol. 268, 37-53.

Wang D, Landick R. 1997. Nuclease cleavage of the upstream half of the nontemplate strand DNA in an Escherichia coli transcription elongation complex causes upstream translocation and transcriptional arrest. J. Biol. Chem. 272, 5989-5994.

Tavromina PL, Landick R, Gross CA. 1996. Isolation, purification, and in vitro characterization of recessive-lethal-mutant RNA polymerases from Escherichia coli. J. Bacteriol. 178, 5263-5371.

Heisler LM, Feng G, Jin DJ, Gross CA, Landick R. 1996. Amino acid substitutions in the two largest subunits of Escherichia coli RNA polymerase that suppress a defective rho termination factor affect different parts of the transcription complex. J. Biol. Chem., 271, 14572-14583.

Yin H, Wang MD, Svoboda K, Landick R, Block SM, Gelles J. 1995. Transcription against an applied force. Science. 270, 1653-1657.

Severinov K, Markov D, Severinova E, Nikiforov V, Landick R, Darst SA, Goldfarb A. 1995. Streptolydigin-resistant mutants in an evolutionarily conserved region of the beta' subunit of Escherichia coli RNA polymerase. J. Biol. Chem. 270, 23926-23929.

Severinov K, Mustaev A, Severinova E, Bass I, Landick R, Nikiforov V, Goldfarb A, Darst SA. 1995. Assembly of functional Escherichia coli RNA polymerase using beta-subunit fragments. Proc. Natl. Acad. Sci. U. S. A. 92, 4591-4595.

Wang D, Meier TI, Chan CL, Feng G, Lee DN, Landick R. 1995. Discontinuous movements of DNA and RNA in E. coli RNA polymerase accompany formation of a paused transcription complex. Cell. 81, 341-350.

Yin H, Landick R, Gelles J. 1994. Tethered particle motion method for studying transcript elongation by a single RNA polymerase molecule. Biophys. J. 67, 2468-2478.

Weilbaecher R, Hebron C, Feng G, Landick R. 1994. Termination-altering amino acid substitutions in the beta' subunit of Escherichia coli RNA polymerase identify regions involved in RNA chain elongation. Genes Dev. 8, 2913-2927.

Darst SA, Stebbins CE, Borukhov S, Orlova M, Feng G, Landick R, Goldfarb A. 1994. Crystallization of GreA, a transcript cleavage factor from Escherichia coli. J. Mol. Biol. 242, 582-585.

Lee DN, Feng G, Landick R. 1994. GreA-induced transcript cleavage is accompanied by reverse translocation to a new transcription complex conformation. J. Biol. Chem. 269, 22295-22303.

Feng G, Lee DN, Wang D, Chan CL, Landick R. 1994. GreA-induced transcript cleavage in transcription complexes containing E. coli RNA polymerase is controlled by multiple factors, including nascent transcript location and structure. J. Biol. Chem. 269, 22282-22294.

Heisler LM, Suzuki H, Landick R, Gross CA. 1993. Four contiguous amino acids define the target for streptolydigin resistance in the beta subunit of Escherichia coli RNA polymerase. J. Biol. Chem. 268, 25369-25375.

Chan CL, Landick R. 1993. Dissection of the his leader pause site by base substitution reveals a multipartite signal that includes a pause RNA hairpin. J. Mol. Biol. 233, 25-42.

Lee DN, Landick R. 1992. Structure of RNA and DNA chains in paused transcription complexes containing Escherichia coli RNA polymerase. J. Mol. Biol. 228, 759-777.

London L, Keene RG, Landick R. 1991. Analysis of premature termination in c-myc during transcription by RNA polymerase II in a HeLa nuclear extract. Mol. Cell. Biol. 11, 4599-4615.

Schafer D, Gelles J, Sheetz M, Landick R. 1991. Transcription by single molecules of RNA polymerase observed by video microscopy. Nature. 352, 444-448.

Landick R, Yanofsky C, Phung L, Choo K. 1990. Replacement of the Escherichia coli trp attenuator control codons alters operon expression. J. Mol. Biol. 216, 25-37.

Landick R, Stewart J, Lee DN. 1990. Amino acid changes in conserved regions of the beta-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination. Genes Dev. 4, 1623-1636.

Lee DN, Phung L, Stewart J, Landick R. 1990. Transcription pausing by Escherichia coli RNA polymerase is modulated by downstream DNA sequences. J. Biol. Chem. 265, 15145-15153.

Adams MD, Wagner LM, Graddis TM, Landick R, Antonucci TK, Gibson AL, Oxender DL. 1990. Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli. J. Biol. Chem. 265, 11436-11443.

Landick R, Colwell A, Stewart J. 1990. Insertional mutagenesis of a plasmid-borne E. coli rpoB gene reveals alterations that inhibit beta-subunit assembly into RNA polymerase. J. Bacteriol. 172, 2844-2854.


1975-1989 return to top

Chan C, Landick R. 1989. The S. typhimurium his operon leader region contains an RNA hairpin-dependent transcription pause site: mechanistic implications of the effect on pausing of altered RNA hairpins. J. Biol. Chem. 264, 20796-20804.

Ti-zhi S, Copeland BR, Landick R, Graddis JT, Oxender DL. 1988. Export of hybrid proteins of leucine-specific binding protein and trypotophan synthetase in Escherichia coli. Acta Biochim. Biophys. Sinica 20, 364-370.

Landick R, Yanofsky C. 1987. Isolation and structural analysis of the Escherichia coli trp leader paused transcription complex. J. Mol. Biol. 196, 363-377.

Landick R, Carey J, Yanofsky C. 1987. Detection of transcription pausing in vivo in the trp operon leader region. Proc. Natl. Acad. Sci. U. S. A. 84, 1507-1511.

Nazos PM, Antonucci TK, Landick R, Oxender DL. 1986. Cloning and characterization of livH, the structural gene encoding a membrane component of the leucine transport system in Escherichia coli. J. Bacteriol. 166, 565-573.

Stewart V, Landick R, Yanofsky C. 1986. Rho-dependent in vitro transcription of the E. coli tryptophanase operon leader region of Escherichia coli K-12. J. Bacteriol. 166, 217-233.

Antonucci TK, Landick R, Oxender DL. 1985. The leucine binding proteins of Escherichia coli as models for studying the relationships between protein structure and function. J. Cell. Biochem. 29, 209-216.

Landick R, Carey J, Yanofsky C. 1985. Translation activates the paused transcription complex and restores transcription of the trp operon leader region. Proc. Natl. Acad. Sci. U. S. A. 82, 4663-4667.

Landick R, Oxender DL. 1985. The complete nucleotide sequences of the E. coli LIV-BP and LS-BP genes: implications for the mechanism of the LIV-I transport system. J. Biol. Chem. 260, 8257-8261.

Landick R, Maguire D, Lutter LC. 1984. Optimization of polyacrylamide gel electrophoresis conditions used for sequencing mixed oligodeoxyribonucleotides. DNA. 3, 414-419.

Landick R, Vaughn V, Lau ET, VanBogelen RA, Erickson JW, Neidhardt FC. 1984. Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein may be a transcription factor. Cell. 38, 175-182.

Landick R, Yanofsky C. 1984. Stability of an RNA secondary structure affects in vitro transcription pausing in the trp operon leader region. J. Biol. Chem. 259, 11550-11555.

Copeland BR, Landick R, Nazos PM, Oxender DL. 1984. Role of membrane potential in protein folding and domain formation during secretion in Escherichia coli. J. Cell. Biochem. 24, 345-356.

Landick R, Duncan JR, Copeland BR, Nazos PM, Oxender DL. 1984. Secretion and degradation of mutant leucine-specific binding protein molecules containing C-terminal deletions. J. Cell. Biochem. 24, 331-344.

Daniels CJ, Anderson JJ, Landick R, Oxender DL. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins. J. Supramol. Struct. 14, 305-311.

Landick R, Anderson JJ, Mayo MM, Gunsalus RP, Mavromara P, Daniels CJ, Oxender DL. 1981. Regulation of the high-affinity leucine transport genes of E. coli. J. Supramol. Struct. 14, 527-537.

Oxender DL, Anderson JJ, Daniels CJ, Landick R, Gunsalus RP, Zurawski G, Yanofsky C. 1980. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and mature form. Proc. Natl. Acad. Sci. U. S. A. 77, 2005-2009.

Oxender DL, Anderson JJ, Daniels CJ, Landick R, Gunsalus RP, Zurawski G, Selker E, Yanofsky C. 1980. Organization and expression of cloned genes for the high-affinity leucine transport system of E. coli. Proc. Natl. Acad. Sci. U. S. A. 77, 1412-1416.

Marino JP, Landick RC. 1975. 1-Phenylthiocyclopropyl-triphenylphosphonium fluroborate: a new synthon for cyclopentanone synthesis. Tetrahedron Lett. 51, 4531-4534.


REVIEWS AND BOOK CHAPTERS

Reviews return to top

Landick R, Wade JT, Grainger DC. 2015. H-NS and RNA polymerase: a love-hate relationship? Curr. Opin. Microbiol. 24, 53-59.

Zhang J, Landick R. 2009. Substrate loading, nucleotide addition, and translocation by RNA polymerase. In RNA Polymerase as Molecular Motors (Buc H, Strick T, eds.), pp. 206-235, Royal Society of Chemistry, London.

Landick R. 2004. Active-site dynamics in RNA polymerases. Cell. 116, 351-353.

Landick R. 2001. RNA polymerase clamps down. Cell. 105, 567-570.

Mooney RA, Landick R. 1999. RNA polymerase unveiled. Cell. 98, 1-4.

Landick R. 1999. Shifting RNA polymerase into overdrive. Science. 284, 598-599.

Mooney RA, Artsimovitch I, Landick R. 1998. Information processing by RNA polymerase: recognition of regulatory signals during RNA chain elongation. J. Bacteriol. 180, 3265-3275.

Gelles J, Landick R. 1998. RNA polymerase as a molecular motor. Cell. 93, 13-16.

Landick R. 1997. RNA polymerase slides home: pause and termination site recognition. Cell. 88, 741-744.

Landick R, Roberts JW. 1996. The shrewd grasp of RNA polymerase. Science. 273, 202-203.

Landick R, Wang D, Chan CL. 1996. Quantitative analysis of transcriptional pausing by RNA polymerase: the his leader pause site as a paradigm. Methods Enzymol. 274, 334-353.


Book Chapters return to top

Geszvain KM, Landick R. 2005. The structure of RNA polymerase. In The Bacterial Chromosome (Higgins NP, ed.), pp. 283-296, American Society for Microbiology, Washington, D.C.

Landick R, Turnbough C Jr, Yanofsky C. 1996. Transcription attenuation. In Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd Edition (Neidhardt FC, Curtiss R 3rd, Ingraham JL, Low KR, B. Magasanik B, Schaechter M, Umbarger HE, eds.), pp. 1263-1286, American Society for Microbiology, Washington, D.C.

Chan CL, Landick R. 1994. New perspectives on transcript elongation and termination by E. coli RNA polymerase. In Transcription: Mechanisms and Regulation (Conaway JW, Conaway RC, eds.), pp. 297-321, Raven Press, New York.

Landick R, Turnbough C Jr. 1992. Transcriptional attenuation. In Transcriptional Regulation (McKnight SL, Yamamoto KR, eds.), pp.407-446, Cold Spring Harbor Press, Cold Spring Harbor, New York.

Landick RC. 1987. The role of the paused transcription complex in trp operon attenuation. In RNA polymerase and the Regulation of Transcription. A Steenbock Symposium (Reznikoff WS, Burgess RR, Dahlberg JE, Gross CA, Record MT Jr, Wickens MP, eds.), pp. 441-444, Elsevier, New York.

Landick R, Yanofsky C. 1987. Transcription attenuation. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt FC, Ingraham JL, Low KR, Magasanik B, Schaechter M, Umbarger HE, eds.), pp. 1276-1301, American Society for Microbiology, Washington, D.C.

Landick R, Oxender DL, Ames GFL. 1985. Bacterial amino acid transport systems. In The Enzymes of Biological Membranes, 2nd Edition, Vol. 3 (Martonosi A, ed.), pp. 577-615, Plenum Press, New York.

Landick R. 1984. Regulation of LIV-I transport system gene expression. In Microbiology 1984 (L. Leive and D. Schlessinger, eds.), pp. 71-74, American Society for Microbiology, Washington, D.C.

Oxender DL, Landick R, Nazos P, Copeland BR. 1984. The role of membrane potential in protein folding and secretion in Escherichia coli. In Microbiology 1984 (Leive L, Schlessinger D, eds.), pp. 4-7, American Society for Microbiology, Washington, D.C.

Nazos PM, Su TZ, Landick R, Oxender DL. 1984. Branched-chain amino acid transport in Escherichia coli. In Microbiology 1984 (Leive L, Schlessinger D, eds.) pp. 24-28, American Society for Microbiology, Washington, D.C.

Copeland BR, Landick R, Nazos PM, Oxender DL. 1984. Role of membrane potential in protein folding and domain formation during secretion in Escherichia coli. In Protein Transport and Secretion (Oxender D, ed.), pp. 279-290, Alan Liss Inc., New York.

Landick R, Duncan JR, Copeland BR, Nazos PM, Oxender DL. 1984. Secretion and degradation of mutant leucine-specific binding protein molecules containing C-terminal deletions. In Protein Transport and Secretion (Oxender D, ed.), pp. 265-278, Alan Liss Inc., New York.

Landick R, Daniels CJ, Oxender DL. 1983. Influence of membrane potential on the insertion and transport of proteins in bacterial membranes. In Methods in Enzymology, Vol. 97, Biomembranes, Part K, Membrane Biogenesis: Assembly and Targeting (Prokaryotes, Mitochondria, and Chloroplasts) (Fleischer S, Fleischer B, eds.), pp. 146-153, Academic Press, New York.

Landick R, Oxender DL. 1982. Bacterial periplasmic binding proteins. In Membranes and Transport: A Critical Review, Vol. 2 (Martonosi A, ed.), pp. 81-91, Plenum Press, New York.

Landick R, Anderson JJ, Mayo MM, Gunsalus RP, Mavromara P, Daniels CJ, Oxender DL. 1981. Regulation of the high-affinity leucine transport genes of E. coli. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (Blume A, Diamond I, Oxender D, Fox CF, eds.), pp. 343-353, Alan Liss Inc., New York.

Daniels CJ, Anderson JJ, Landick R, Oxender DL. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (Blume A, Diamond I, Oxender D, Fox CF, eds.), pp. 319-325, Alan Liss Inc., New York.