RNA polymerase is the central enzyme of gene expression in all free-living organisms. We seek to understand how the fundamental properties of RNA polymerase, largely conserved from bacteria to human, make it susceptible to pausing, arrest, or termination and how elongation regulators, nucleoprotein structures, and metabolic, developmental, and environmental signals alter these properties.
We study the mechanisms by which gene expression by RNA polymerase is regulated and can be re-programmed for biodesign, and how these basic research advances can be applied to microbial biotechnology and to antibiotic discovery. Members of our lab develop and apply expertise from a variety of scientific disciplines, including genetics, biomolecular chemistry, synthetic biology, systems biology, biophysics, and structural biology, to both individual and collaborative projects.
Junqiao Zhu has joined our lab as a graduate student. He will be co-mentored by Dr. Landick and Dr. Aaron Hoskins. Welcome!
Jess Vera and Kayley Janssen left our lab at the end of October. Jess has taken a new position in the Center for High Throughput Computing in the Wisconsin Institutes for Discovery, and Kayley accepted …
Michael Wolfe has joined our lab as a postdoctoral researcher. He comes to us from Peter Freddolino’s lab at the University of Michigan. Welcome!