A full list of publications from our lab can be found here.
2023
Lan F, Saba J, Qian Y, Ross T, Landick R, Venturelli OS. 2023. Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity. Sci Adv. 9, eadg5476. https://doi.org/10.1126/sciadv.adg5476
Delbeau M, Omollo EO, Froom R, Koh S, Mooney RA, Lilic M, Brewer JJ, Rock J, Darst SA, Campbell EA, Landick R. 2023. Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol Cell. 83, 1474-1488.e8. https://doi.org/10.1016/j.molcel.2023.04.007
Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R. 2023. An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc Natl Acad Sci U S A. 120, e2215945120. https://doi.org/10.1073/pnas.2215945120
Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA. 2023. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. 614, 781-787. https://doi.org/10.1038/s41586-022-05664-3
You L, Omollo EO, Yu C, Mooney RA, Shi J, Shen L, Wu X, Wen A, He D, Zeng Y, Feng Y, Landick R, Zhang Y. 2023. Structural basis for intrinsic transcription termination. Nature. 613, 783-789. https://doi.org/10.1038/s41586-022-05604-1
2022
Hustmyer CM, Wolfe MB, Welch RA, Landick R. 2022. RfaH counter-silences inhibition of transcript elongation by H-NS-StpA nucleoprotein filaments in pathogenic Escherichia coli. mBio. 13, e0266222. https://doi.org/10.1128/mbio.02662-22
Zhang Y, Myers KS, Place M, Serate J, Xie D, Pohlmann E, La Reau A, Landick R, Sato TK. 2022. Transcriptomic data sets for Zymomonas mobilis 2032 during fermentation of ammonia fiber expansion (AFEX)-pretreated corn stover and switchgrass hydrolysates. Microbiol Resour Announc. 11, e0056422. https://doi.org/10.1128/mra.00564-22
Cao X, Landick R, Campbell EA. 2022. A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens. Microb Cell. 9, 136-138. https://doi.org/10.15698/mic2022.07.780
Shen BA, Hustmyer CM, Roston D, Wolfe MB, Landick R. 2022. Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments. iScience. 25, 104429. https://doi.org/10.1016/j.isci.2022.104429
Cao X, Boyaci H, Chen J, Bao Y, Landick R, Campbell EA. 2022. Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature. 604, 541-545. https://doi.org/10.1038/s41586-022-04545-z
2021
Dai W, Darst SA, Dunham CM, Landick R, Petsko G, Weixlbaumer A. 2021. Seeing gene expression in cells: the future of structural biology. Fac Rev. 10, 79. https://doi.org/10.12703/r-01-000004
Palo MZ, Zhu J, Mishanina TV, Landick R. 2021. Conserved trigger loop histidine of RNA polymerase II functions as a positional catalyst primarily through steric effects. Biochemistry. 60, 3323-3336. https://doi.org/10.1021/acs.biochem.1c00528
Lee SB, Tremaine M, Place M, Liu L, Pier A, Krause DJ, Xie D, Zhang Y, Landick R, Gasch AP, Hittinger CT, Sato TK. 2021. Crabtree/Warburg-like aerobic xylose fermentation by engineered Saccharomyces cerevisiae. Metab Eng. 68, 119-130. https://doi.org/10.1016/j.ymben.2021.09.008
Bao Y, Landick R. 2021. Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe pocket anchor. Proc Natl Acad Sci U S A. 118, e2101805118. https://doi.org/10.1073/pnas.2101805118
Landick R. 2021. Transcriptional pausing as a mediator of bacterial gene regulation. Annu Rev Microbiol. 75, 291-314. https://doi.org/10.1146/annurev-micro-051721-043826
Shiver AL, Osadnik H, Peters JM, Mooney RA, Wu PI, Henry KK, Braberg H, Krogan NJ, Hu JC, Landick R, Huang KC, Gross CA. 2021. Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs. Mol Cell. 81, 2201-2215.e9. https://doi.org/10.1016/j.molcel.2021.04.027
Malone B, Chen J, Wang Q, Llewellyn E, Choi YJ, Olinares PDB, Cao X, Hernandez C, Eng ET, Chait BT, Shaw DE, Landick R, Darst SA, Campbell EA. 2021. Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc Natl Acad Sci U S A. 118, e2102516118. https://doi.org/10.1073/pnas.2102516118
Saba J, Cao X, Landick R. 2021. Bacterial transcription continues to surprise: activation by alarmone-mediated σ-factor tethering. Mol Cell. 81, 8-9. https://doi.org/10.1016/j.molcel.2020.12.031