A full list of publications from our lab can be found here.
2022
Shen BA, Hustmyer CM, Roston D, Wolfe MB, Landick R. 2022. Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments. iScience. 25, 104429. https://doi.org/10.1016/j.isci.2022.104429
Cao X, Boyaci H, Chen J, Bao Y, Landick R, Campbell EA. 2022. Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature. 604, 541-545. https://doi.org/10.1038/s41586-022-04545-z
2021
Dai W, Darst SA, Dunham CM, Landick R, Petsko G, Weixlbaumer A. 2021. Seeing gene expression in cells: the future of structural biology. Fac Rev. 10, 79. https://doi.org/10.12703/r-01-000004
Palo MZ, Zhu J, Mishanina TV, Landick R. 2021. Conserved trigger loop histidine of RNA polymerase II functions as a positional catalyst primarily through steric effects. Biochemistry. 60, 3323-3336. https://doi.org/10.1021/acs.biochem.1c00528
Lee SB, Tremaine M, Place M, Liu L, Pier A, Krause DJ, Xie D, Zhang Y, Landick R, Gasch AP, Hittinger CT, Sato TK. 2021. Crabtree/Warburg-like aerobic xylose fermentation by engineered Saccharomyces cerevisiae. Metab Eng. 68, 119-130. https://doi.org/10.1016/j.ymben.2021.09.008
Bao Y, Landick R. 2021. Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe pocket anchor. Proc Natl Acad Sci U S A. 118, e2101805118. https://doi.org/10.1073/pnas.2101805118
Landick R. 2021. Transcriptional pausing as a mediator of bacterial gene regulation. Annu Rev Microbiol. 75, 291-314. https://doi.org/10.1146/annurev-micro-051721-043826
Shiver AL, Osadnik H, Peters JM, Mooney RA, Wu PI, Henry KK, Braberg H, Krogan NJ, Hu JC, Landick R, Huang KC, Gross CA. 2021. Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs. Mol Cell. 81, 2201-2215.e9. https://doi.org/10.1016/j.molcel.2021.04.027
Malone B, Chen J, Wang Q, Llewellyn E, Choi YJ, Olinares PDB, Cao X, Hernandez C, Eng ET, Chait BT, Shaw DE, Landick R, Darst SA, Campbell EA. 2021. Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc Natl Acad Sci U S A. 118, e2102516118. https://doi.org/10.1073/pnas.2102516118
Saba J, Cao X, Landick R. 2021. Bacterial transcription continues to surprise: activation by alarmone-mediated σ-factor tethering. Mol Cell. 81, 8-9. https://doi.org/10.1016/j.molcel.2020.12.031
2020
Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. 2020. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A. 117, 30423-30432. https://doi.org/10.1073/pnas.2013706117
Henry KK, Ross W, Myers KS, Lemmer KC, Vera JM, Landick R, Donohue TJ, Gourse RL. 2020. A majority of Rhodobacter sphaeroides promoters lack a crucial RNA polymerase recognition feature, enabling coordinated transcription activation. Proc Natl Acad Sci U S A. 117, 29658-29668. https://doi.org/10.1073/pnas.2010087117
Stoneman HR, Wrobel RL, Place M, Graham M, Krause DJ, De Chiara M, Liti G, Schacherer J, Landick R, Gasch AP, Sato TK, Hittinger CT. 2020. CRISpy-Pop: a web tool for designing CRISPR/Cas9-driven genetic modifications in diverse populations. G3 (Bethesda). 10, 4287-4294. https://doi.org/10.1534/g3.120.401498
Myers KS, Vera JM, Lemmer KC, Linz AM, Landick R, Noguera DR, Donohue TJ. 2020. Genome-wide identification of transcription start sites in two Alphaproteobacteria, Rhodobacter sphaeroides 2.4.1 and Novosphingobium aromaticivorans DSM 12444. Microbiol Resour Announc. 9, e00880-20. https://doi.org/10.1128/MRA.00880-20
Kurumbang NP, Vera JM, Hebert AS, Coon JJ, Landick R. 2020. Heterologous expression of a glycosyl hydrolase and cellular reprogramming enable Zymomonas mobilis growth on cellobiose. PLoS One. 15, e0226235. https://doi.org/10.1371/journal.pone.0226235
Vera JM, Ghosh IN, Zhang Y, Hebert AS, Coon JJ, Landick R. 2020. Genome-scale transcription-translation mapping reveals features of Zymomonas mobilis transcription units and promoters. mSystems. 5, e00250-20. https://doi.org/10.1128/mSystems.00250-20
Liu Y, Ghosh IN, Martien JI, Zhang Y, Amador-Noguez D, Landick R. 2020. Regulated redirection of central carbon flux enhances anaerobic production of bioproducts in Zymomonas mobilis. Metab Eng. 61, 261-274. https://doi.org/10.1016/j.ymben.2020.06.005
Harden TT, Herlambang KS, Chamberlain M, Lalanne JB, Wells CD, Li GW, Landick R, Hochschild A, Kondev J, Gelles J. 2020. Alternative transcription cycle for bacterial RNA polymerase. Nat Commun. 11, 448. https://doi.org/10.1038/s41467-019-14208-9