A full list of publications from our lab can be found here.
2025
Barten LM, Crandall JG, Xie D, Serate J, Handowski E, Jen A, Overmyer KA, Coon JJ, Hittinger CT, Landick R, Zhang Y, Sato TK. 2025. pH adjustment increases biofuel production from inhibitory switchgrass hydrolysates. bioRxiv (preprint). https://doi.org/10.1101/2025.01.10.632484
Brewer JJ, Inlow K, Mooney RA, Bosch B, Olinares PDB, Marcelino LP, Chait BT, Landick R, Gelles J, Campbell EA, Darst SA. 2025. RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation. Nat Struct Mol Biol. In press. https://doi.org/10.1038/s41594-024-01447-8
Mooney RA, Zhu J, Saba J, Landick R. 2025. NusG-Spt5 transcription factors: universal, dynamic modulators of gene expression. J Mol Biol. 437, 168814. https://doi.org/10.1016/j.jmb.2024.168814
2024
Saba J, Flores K, Marshall B, Engstrom MD, Peng Y, Garje AS, Comstock L, Landick R. 2024. Bacteroides expand the functional versatility of a universal transcription factor and transcribed DNA to program capsule diversity. Nat Commun. 15, 10862. https://doi.org/10.1038/s41467-024-55215-9
Delbeau M, Froom R, Landick R, Darst SA, Campbell EA. 2024. The yin and yang of the universal transcription factor NusG. Curr Opin Microbiol. 81, 102540. https://doi.org/10.1016/j.mib.2024.102540
Boudreau BA, Hustmyer CM, Kotlajich MV, Landick R. 2024. In vitro transcription assay to quantify effects of H-NS filaments on RNA chain elongation by RNA polymerase. Methods Mol Biol. 2819, 381-419. https://doi.org/10.1007/978-1-0716-3930-6_18
Hustmyer CM, Landick R. 2024. Bacterial chromatin proteins, transcription, and DNA topology: inseparable partners in the control of gene expression. Mol Microbiol. 122, 81-112. https://doi.org/10.1111/mmi.15283
Bao Y, Cao X, Landick R. 2024. RNA polymerase SI3 domain modulates global transcriptional pausing and pause-site fluctuations. Nucleic Acids Res. 52, 4556-4574. https://doi.org/10.1093/nar/gkae209
Eckartt KA, Delbeau M, Munsamy-Govender V, DeJesus MA, Azadian ZA, Reddy AK, Chandanani J, Poulton NC, Quiñones-Garcia S, Bosch B, Landick R, Campbell EA, Rock JM. 2024. Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis. Nature. 628, 186-194. https://doi.org/10.1038/s41586-024-07206-5
Lan F, Saba J, Ross TD, Zhou Z, Krauska K, Anantharaman K, Landick R, Venturelli OS. 2024. Massively parallel single-cell sequencing of diverse microbial populations. Nat Methods. 21, 228-235. https://doi.org/10.1038/s41592-023-02157-7 Correction in: Nat Methods. https://doi.org/10.1038/s41592-024-02570-6.
2023
Marshall B, Amritkar K, Wolfe M, Kaçar B, Landick R. 2023. Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway. Front Microbiol. 14, 1286626. https://doi.org/10.3389/fmicb.2023.1286626
Lan F, Saba J, Qian Y, Ross T, Landick R, Venturelli OS. 2023. Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity. Sci Adv. 9, eadg5476. https://doi.org/10.1126/sciadv.adg5476
Delbeau M, Omollo EO, Froom R, Koh S, Mooney RA, Lilic M, Brewer JJ, Rock J, Darst SA, Campbell EA, Landick R. 2023. Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol Cell. 83, 1474-1488.e8. https://doi.org/10.1016/j.molcel.2023.04.007
Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R. 2023. An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc Natl Acad Sci U S A. 120, e2215945120. https://doi.org/10.1073/pnas.2215945120
Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA. 2023. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. 614, 781-787. https://doi.org/10.1038/s41586-022-05664-3
You L, Omollo EO, Yu C, Mooney RA, Shi J, Shen L, Wu X, Wen A, He D, Zeng Y, Feng Y, Landick R, Zhang Y. 2023. Structural basis for intrinsic transcription termination. Nature. 613, 783-789. https://doi.org/10.1038/s41586-022-05604-1