The Landick Lab
Researching fundamental and applied paradigms of gene regulation

All Publications

Below is a full list of publications from the Landick lab, including original research articles, literature reviews, protocols, and book chapters. All links will open in a new tab.

Landick publications search on PubMed (link opens in new tab)

  1. Saba J, Flores K, Marshall B, Engstrom MD, Peng Y, Garje AS, Comstock L, Landick R. 2024. Bacteroides expand the functional versatility of a universal transcription factor and transcribed DNA to program capsule diversity. bioRxiv (preprint). https://doi.org/10.1101/2024.06.21.599965
  2. Mooney RA, Zhu J, Saba J, Landick R. 2024. NusG-Spt5 transcription factors: universal, dynamic modulators of gene expression. J Mol Biol. In press. https://doi.org/10.1016/j.jmb.2024.168814
  3. Delbeau M, Froom R, Landick R, Darst SA, Campbell EA. 2024. The yin and yang of the universal transcription factor NusG. Curr Opin Microbiol. 81, 102540. https://doi.org/10.1016/j.mib.2024.102540
  4. Boudreau BA, Hustmyer CM, Kotlajich MV, Landick R. 2024. In vitro transcription assay to quantify effects of H-NS filaments on RNA chain elongation by RNA polymerase. Methods Mol Biol. 2819, 381-419. https://doi.org/10.1007/978-1-0716-3930-6_18
  5. Hustmyer CM, Landick R. 2024. Bacterial chromatin proteins, transcription, and DNA topology: inseparable partners in the control of gene expression. Mol Microbiol. 122, 81-112. https://doi.org/10.1111/mmi.15283
  6. Bao Y, Cao X, Landick R. 2024. RNA polymerase SI3 domain modulates global transcriptional pausing and pause-site fluctuations. Nucleic Acids Res. 52, 4556-4574. https://doi.org/10.1093/nar/gkae209
  7. Eckartt KA, Delbeau M, Munsamy-Govender V, DeJesus MA, Azadian ZA, Reddy AK, Chandanani J, Poulton NC, Quiñones-Garcia S, Bosch B, Landick R, Campbell EA, Rock JM. 2024. Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis. Nature. 628, 186-194. https://doi.org/10.1038/s41586-024-07206-5
  8. Lan F, Saba J, Ross TD, Zhou Z, Krauska K, Anantharaman K, Landick R, Venturelli OS. 2024. Massively parallel single-cell sequencing of diverse microbial populations. Nat Methods. 21, 228-235. https://doi.org/10.1038/s41592-023-02157-7
  9. Marshall B, Amritkar K, Wolfe M, Kaçar B, Landick R. 2023. Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway. Front Microbiol. 14, 1286626. https://doi.org/10.3389/fmicb.2023.1286626
  10. Lan F, Saba J, Qian Y, Ross T, Landick R, Venturelli OS. 2023. Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity. Sci Adv. 9, eadg5476. https://doi.org/10.1126/sciadv.adg5476
  11. Delbeau M, Omollo EO, Froom R, Koh S, Mooney RA, Lilic M, Brewer JJ, Rock J, Darst SA, Campbell EA, Landick R. 2023. Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis. Mol Cell. 83, 1474-1488.e8. https://doi.org/10.1016/j.molcel.2023.04.007
  12. Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R. 2023. An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proc Natl Acad Sci U S A. 120, e2215945120. https://doi.org/10.1073/pnas.2215945120
  13. Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA. 2023. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. 614, 781-787. https://doi.org/10.1038/s41586-022-05664-3
  14. You L, Omollo EO, Yu C, Mooney RA, Shi J, Shen L, Wu X, Wen A, He D, Zeng Y, Feng Y, Landick R, Zhang Y. 2023. Structural basis for intrinsic transcription termination. Nature. 613, 783-789. https://doi.org/10.1038/s41586-022-05604-1
  15. Hustmyer CM, Wolfe MB, Welch RA, Landick R. 2022. RfaH counter-silences inhibition of transcript elongation by H-NS-StpA nucleoprotein filaments in pathogenic Escherichia coli. mBio. 13, e0266222. https://doi.org/10.1128/mbio.02662-22
  16. Zhang Y, Myers KS, Place M, Serate J, Xie D, Pohlmann E, La Reau A, Landick R, Sato TK. 2022. Transcriptomic data sets for Zymomonas mobilis 2032 during fermentation of ammonia fiber expansion (AFEX)-pretreated corn stover and switchgrass hydrolysates. Microbiol Resour Announc. 11, e0056422. https://doi.org/10.1128/mra.00564-22
  17. Cao X, Landick R, Campbell EA. 2022. A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens. Microb Cell. 9, 136-138. https://doi.org/10.15698/mic2022.07.780
  18. Shen BA, Hustmyer CM, Roston D, Wolfe MB, Landick R. 2022. Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments. iScience. 25, 104429. https://doi.org/10.1016/j.isci.2022.104429
  19. Cao X, Boyaci H, Chen J, Bao Y, Landick R, Campbell EA. 2022. Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature. 604, 541-545. https://doi.org/10.1038/s41586-022-04545-z
  20. Dai W, Darst SA, Dunham CM, Landick R, Petsko G, Weixlbaumer A. 2021. Seeing gene expression in cells: the future of structural biology. Fac Rev. 10, 79. https://doi.org/10.12703/r-01-000004
  21. Palo MZ, Zhu J, Mishanina TV, Landick R. 2021. Conserved trigger loop histidine of RNA polymerase II functions as a positional catalyst primarily through steric effects. Biochemistry. 60, 3323-3336. https://doi.org/10.1021/acs.biochem.1c00528
  22. Lee SB, Tremaine M, Place M, Liu L, Pier A, Krause DJ, Xie D, Zhang Y, Landick R, Gasch AP, Hittinger CT, Sato TK. 2021. Crabtree/Warburg-like aerobic xylose fermentation by engineered Saccharomyces cerevisiae. Metab Eng. 68, 119-130. https://doi.org/10.1016/j.ymben.2021.09.008
  23. Bao Y, Landick R. 2021. Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe pocket anchor. Proc Natl Acad Sci U S A. 118, e2101805118. https://doi.org/10.1073/pnas.2101805118
  24. Landick R. 2021. Transcriptional pausing as a mediator of bacterial gene regulation. Annu Rev Microbiol. 75, 291-314. https://doi.org/10.1146/annurev-micro-051721-043826
  25. Shiver AL, Osadnik H, Peters JM, Mooney RA, Wu PI, Henry KK, Braberg H, Krogan NJ, Hu JC, Landick R, Huang KC, Gross CA. 2021. Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs. Mol Cell. 81, 2201-2215.e9. https://doi.org/10.1016/j.molcel.2021.04.027
  26. Malone B, Chen J, Wang Q, Llewellyn E, Choi YJ, Olinares PDB, Cao X, Hernandez C, Eng ET, Chait BT, Shaw DE, Landick R, Darst SA, Campbell EA. 2021. Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc Natl Acad Sci U S A. 118, e2102516118. https://doi.org/10.1073/pnas.2102516118
  27. Saba J, Cao X, Landick R. 2021. Bacterial transcription continues to surprise: activation by alarmone-mediated σ-factor tethering. Mol Cell. 81, 8-9. https://doi.org/10.1016/j.molcel.2020.12.031
  28. Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. 2020. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A. 117, 30423-30432. https://doi.org/10.1073/pnas.2013706117
  29. Henry KK, Ross W, Myers KS, Lemmer KC, Vera JM, Landick R, Donohue TJ, Gourse RL. 2020. A majority of Rhodobacter sphaeroides promoters lack a crucial RNA polymerase recognition feature, enabling coordinated transcription activation. Proc Natl Acad Sci U S A. 117, 29658-29668. https://doi.org/10.1073/pnas.2010087117
  30. Stoneman HR, Wrobel RL, Place M, Graham M, Krause DJ, De Chiara M, Liti G, Schacherer J, Landick R, Gasch AP, Sato TK, Hittinger CT. 2020. CRISpy-Pop: a web tool for designing CRISPR/Cas9-driven genetic modifications in diverse populations. G3 (Bethesda). 10, 4287-4294. https://doi.org/10.1534/g3.120.401498
  31. Myers KS, Vera JM, Lemmer KC, Linz AM, Landick R, Noguera DR, Donohue TJ. 2020. Genome-wide identification of transcription start sites in two Alphaproteobacteria, Rhodobacter sphaeroides 2.4.1 and Novosphingobium aromaticivorans DSM 12444. Microbiol Resour Announc. 9, e00880-20. https://doi.org/10.1128/MRA.00880-20
  32. Kurumbang NP, Vera JM, Hebert AS, Coon JJ, Landick R. 2020. Heterologous expression of a glycosyl hydrolase and cellular reprogramming enable Zymomonas mobilis growth on cellobiose. PLoS One. 15, e0226235. https://doi.org/10.1371/journal.pone.0226235
  33. Vera JM, Ghosh IN, Zhang Y, Hebert AS, Coon JJ, Landick R. 2020. Genome-scale transcription-translation mapping reveals features of Zymomonas mobilis transcription units and promoters. mSystems. 5, e00250-20. https://doi.org/10.1128/mSystems.00250-20
  34. Liu Y, Ghosh IN, Martien JI, Zhang Y, Amador-Noguez D, Landick R. 2020. Regulated redirection of central carbon flux enhances anaerobic production of bioproducts in Zymomonas mobilis. Metab Eng. 61, 261-274. https://doi.org/10.1016/j.ymben.2020.06.005
  35. Harden TT, Herlambang KS, Chamberlain M, Lalanne JB, Wells CD, Li GW, Landick R, Hochschild A, Kondev J, Gelles J. 2020. Alternative transcription cycle for bacterial RNA polymerase. Nat Commun. 11, 448. https://doi.org/10.1038/s41467-019-14208-9
  36. Zhang Y, Vera JM, Xie D, Serate J, Pohlmann E, Russell JD, Hebert AS, Coon JJ, Sato TK, Landick R. 2019. Multiomic fermentation using chemically defined synthetic hydrolyzates revealed multiple effects of lignocellulose-derived inhibitors on cell physiology and xylose utilization in Zymomonas mobilis. Front Microbiol. 10, 2596. https://doi.org/10.3389/fmicb.2019.02596
  37. Lal PB, Wells FM, Lyu Y, Ghosh IN, Landick R, Kiley PJ. 2019. A markerless method for genome engineering in Zymomonas mobilis ZM4. Front Microbiol. 10, 2216. https://doi.org/10.3389/fmicb.2019.02216
  38. Kim J, Tremaine M, Grass JA, Purdy HM, Landick R, Kiley PJ, Reed JL. 2019. Systems metabolic engineering of Escherichia coli improves coconversion of lignocellulose-derived sugars. Biotechnol J. 14, e1800441. https://doi.org/10.1002/biot.201800441
  39. Shen BA, Landick R. 2019. Transcription of bacterial chromatin. J Mol Biol. 431, 4040-4066. https://doi.org/10.1016/j.jmb.2019.05.041
  40. Kang JY, Mishanina TV, Landick R, Darst SA. 2019. Mechanisms of transcriptional pausing in bacteria. J Mol Biol. 431, 4007-4029. https://doi.org/10.1016/j.jmb.2019.07.017
  41. Liu Y, Landick R, Raman S. 2019. A regulatory NADH/NAD+ redox biosensor for bacteria. ACS Synth Biol. 8, 264-273. https://doi.org/10.1021/acssynbio.8b00485
  42. Stumper SK, Ravi H, Friedman LJ, Mooney RA, Corrêa IR, Gershenson A, Landick R, Gelles J. 2019. Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription. eLife. 8, e40576. https://doi.org/10.7554/eLife.40576
  43. Bellecourt MJ, Ray-Soni A, Harwig A, Mooney RA, Landick R. 2019. RNA polymerase clamp movement aids dissociation from DNA but is not required for RNA release at intrinsic terminators. J Mol Biol. 431, 696-713. https://doi.org/10.1016/j.jmb.2019.01.003
  44. Saba J, Chua XY, Mishanina TV, Nayak D, Windgassen TA, Mooney RA, Landick R. 2019. The elemental mechanism of transcriptional pausing. eLife. 8, e40981. https://doi.org/10.7554/eLife.40981
  45. Ghosh IN, Martien J, Hebert AS, Zhang Y, Coon JJ, Amador-Noguez D, Landick R. 2019. OptSSeq explores enzyme expression and function landscapes to maximize isobutanol production rate. Metab Eng. 52, 324-340. https://doi.org/10.1016/j.ymben.2018.12.008
  46. Lawson MR, Ma W, Bellecourt MJ, Artsimovitch I, Martin A, Landick R, Schulten K, Berger JM. 2018. Mechanism for the regulated control of bacterial transcription termination by a universal adaptor protein. Mol Cell. 71, 911-922.e4. https://doi.org/10.1016/j.molcel.2018.07.014
  47. Boudreau BA, Kotlajich MV, Landick R. 2018. In vitro transcription assay to quantify effects of H-NS filaments on RNA chain elongation by RNA polymerase. In: Dame R. (eds) Bacterial Chromatin. Methods in Molecular Biology, vol 1837, pp. 351-386. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8675-0_18
  48. Higgins DA, Young MKM, Tremaine M, Sardi M, Fletcher JM, Agnew M, Liu L, Dickinson Q, Peris D, Wrobel RL, Hittinger CT, Gasch AP, Singer SW, Simmons BA, Landick R, Thelen MP, Sato TK. 2018. Natural variation in the multidrug efflux pump SGE1 underlies ionic liquid tolerance in yeast. Genetics. 210, 219-234. https://doi.org/10.1534/genetics.118.301161
  49. Kang JY, Mooney RA, Nedialkov Y, Saba J, Mishanina TV, Artsimovitch I, Landick R, Darst SA. 2018. Structural basis for transcript elongation control by NusG family universal regulators. Cell. 173, 1650-1662.e14. https://doi.org/10.1016/j.cell.2018.05.017
  50. Yang S, Vera JM, Grass J, Savvakis G, Moskvin OV, Yang Y, McIlwain SJ, Lyu Y, Zinonos I, Hebert AS, Coon JJ, Bates DM, Sato TK, Brown SD, Himmel ME, Zhang M, Landick R, Pappas KM, Zhang Y. 2018. Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032. Biotechnol Biofuels. 11, 125. https://doi.org/10.1186/s13068-018-1116-x
  51. Boudreau BA, Hron DR, Qin L, van der Valk RA, Kotlajich MV, Dame RT, Landick R. 2018. StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments. Nucleic Acids Res. 46, 5525-5546. https://doi.org/10.1093/nar/gky265
  52. Helmling C, Klotzner DP, Sochor F, Mooney RA, Wacker A, Landick R, Furtig B, Heckel A, Schwalbe H. 2018. Life times of metastable states guide regulatory signaling in transcriptional riboswitches. Nat Commun. 9, 944. https://doi.org/10.1038/s41467-018-03375-w
  53. Kang J, Mishanina TV, Bellecourt MJ, Mooney RA, Darst SA, Landick R. 2018. RNA polymerase accommodates a pause RNA hairpin by global conformational rearrangements that prolong pausing. Mol Cell. 69, 802-815.e1. https://doi.org/10.1016/j.molcel.2018.01.018
  54. Boyaci H, Chen J, Lilic M, Palka M, Mooney RA, Landick R, Darst SA, Campbell EA. 2018. Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts. Elife. 7, e34823. https://doi.org/10.7554/eLife.34823
  55. Bottoms S, Dickinson Q, McGee M, Hinchman L, Higbee A, Hebert A, Serate J, Xie D, Zhang Y, Coon JJ, Myers CL, Landick R, Piotrowski JS. 2018. Chemical genomic guided engineering of gamma-valerolactone tolerant yeast. Microb Cell Fact. 17, 5. https://doi.org/10.1186/s12934-017-0848-9
  56. Ray-Soni A, Mooney RA, Landick R. 2017. Trigger loop dynamics can explain stimulation of intrinsic termination by bacterial RNA polymerase without terminator hairpin contact. Proc Natl Acad Sci U S A. 114, E9233-E9242. https://doi.org/10.1073/pnas.1706247114
  57. Harwig A, Landick R, Berkhout B. 2017. The battle of RNA synthesis: virus versus host. Viruses. 9, E309. https://doi.org/10.3390/v9100309
  58. Welch R, Chung D, Grass J, Landick R, Keles S. 2017. Data exploration, quality control and statistical analysis of ChIP-exo/nexus experiments. Nucleic Acids Res. 45, e145. https://doi.org/10.1093/nar/gkx594
  59. Mishanina TV, Palo MZ, Nayak D, Mooney RA, Landick R. 2017. Trigger loop of RNA polymerase is a positional, not acid-base, catalyst for both transcription and proofreading. Proc Natl Acad Sci U S A. 114, E5103-E5112. https://doi.org/10.1073/pnas.1702383114
  60. Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R, Darst SA. 2017. RNA polymerase motions during promoter melting. Science. 356, 863-866. https://doi.org/10.1126/science.aam7858
  61. Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Furtig B, Wohnert J, Schwalbe H. 2017. Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation. Elife. 6, e21297. https://doi.org/10.7554/eLife.21297
  62. Kohler R, Mooney RA, Mills DJ, Landick R, Cramer P. 2017. Architecture of a transcribing-translating expressome. Science. 356, 194-197. https://doi.org/10.1126/science.aal3059
  63. Tetone LE, Friedman LJ, Osborne ML, Ravi H, Kyzer S, Stumper SK, Mooney RA, Landick R, Gelles J. 2017. Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proc Natl Acad Sci U S A. 114, E1081-E1090. https://doi.org/10.1073/pnas.1616525114
  64. Sato TK, Tremaine M, Parreiras LS, Hebert AS, Myers KS, Higbee AJ, Sardi M, McIlwain SJ, Ong IM, Breuer RJ, Narasimhan RA, McGee MA, Dickinson Q, La Reau A, Xie D, Tian M, Piotrowski JS, Reed JL, Zhang Y, Coon JJ, Hittinger CT, Gasch AP, Landick R. 2016. Directed evolution reveals unexpected epistatic interactions that alter metabolic regulation and enable anaerobic xylose use by Saccharomyces cerevisiae. PLoS Genet. 12, e1006372. Erratum published in PLoS Genet., 12, e1006447. https://doi.org/10.1371/journal.pgen.1006372
  65. Ghosh IN, Landick R. 2016. OptSSeq: High-throughput sequencing readout of growth enrichment defines optimal gene expression elements for homoethanologenesis. ACS Synth Biol. 5, 1519-1534. https://doi.org/10.1021/acssynbio.6b00121
  66. McIlwain SJ, Peris D, Sardi M, Moskvin OV, Zhan F, Myers K, Riley NM, Buzzell A, Parreiras LS, Ong IM, Landick R, Coon JJ, Gasch AP, Sato TK, Hittinger CT. 2016. Genome sequence and analysis of a stress-tolerant, wild-derived strain of Saccharomyces cerevisiae used in biofuels research. G3 (Bethesda). 6, 1757-1766. https://doi.org/10.1534/g3.116.029389
  67. Ray-Soni A, Bellecourt MJ, Landick R. 2016. Mechanisms of bacterial transcription termination: all good things must end. Annu Rev Biochem. 85, 319-347. https://doi.org/10.1146/annurev-biochem-060815-014844
  68. Zhang J, Landick R. 2016. A two-way street: regulatory interplay between RNA polymerase and nascent RNA structure. Trends Biochem Sci. 41, 293-310. https://doi.org/10.1016/j.tibs.2015.12.009
  69. Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS. 2016. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain. Microb Cell Fact. 15, 17. https://doi.org/10.1186/s12934-016-0417-7
  70. Ronayne EA, Wan YC, Boudreau BA, Landick R, Cox MM. 2016. P1 ref endonuclease: a molecular mechanism for phage-enhanced antibiotic lethality. PLoS Genet. 12, e1005797. https://doi.org/10.1371/journal.pgen.1005797
  71. Harden TT, Wells CD, Friedman LJ, Landick R, Hochschild A, Kondev J, Gelles J. 2016. Bacterial RNA polymerase can retain sigma70 throughout transcription. Proc Natl Acad Sci U S A. 113, 602-607. https://doi.org/10.1073/pnas.1513899113
  72. Landick R, Wade JT, Grainger DC. 2015. H-NS and RNA polymerase: a love-hate relationship? Curr Opin Microbiol. 24, 53-59. https://doi.org/10.1016/j.mib.2015.01.009
  73. Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y. 2015. Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation. Biotechnol Biofuels. 8, 180. https://doi.org/10.1186/s13068-015-0356-2
  74. Bae B, Feklistov A, Lass-Napiorkowska A, Landick R, Darst SA. 2015. Structure of a bacterial RNA polymerase holoenzyme open promoter complex. eLife. 4, e08504. https://doi.org/10.7554/eLife.08504
  75. Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y. 2015. Plant-derived antifungal agent poacic acid targets beta-1,3-glucan. Proc Natl Acad Sci U S A. 112, E1490-1497. https://doi.org/10.1073/pnas.1410400112
  76. Bae B, Nayak D, Ray A, Mustaev A, Landick R, Darst SA. 2015. CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc Natl Acad Sci U S A. 112, E4178-E4187. https://doi.org/10.1073/pnas.1502368112
  77. Kotlajich MV, Hron DR, Boudreau BA, Sun Z, Lyubchenko YL, Landick R. 2015. Bridged filaments of histone-like nucleoid structuring protein pause RNA polymerase and aid termination in bacteria. eLife. 4, e04970. https://doi.org/10.7554/eLife.04970
  78. Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R. 2014. Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase. Nucleic Acids Res. 42, 12707-12721. https://doi.org/10.1093/nar/gku997
  79. Hein PP, Kolb KE, Windgassen T, Bellecourt MJ, Darst SA, Mooney RA, Landick R. 2014. RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movement. Nat Struct Mol Biol. 21, 794-802. https://doi.org/10.1038/nsmb.2867
  80. Haft RJ, Keating DH, Schwaegler T, Schwalbach MS, Vinokur J, Tremaine M, Peters JM, Kotlajich MV, Pohlmann EL, Ong IM, Grass JA, Kiley PJ, Landick R. 2014. Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria. Proc Natl Acad Sci U S A. 111, E2576-E2585. https://doi.org/10.1073/pnas.1401853111
  81. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. 2014. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 344, 1042-1047. https://doi.org/10.1126/science.1251871
  82. Czyz A, Mooney RA, Iaconi A, Landick R. 2014. Mycobacterial RNA polymerase requires a U-tract at intrinsic terminators and is aided by NusG at suboptimal terminators. MBio. 5, e00931. https://doi.org/10.1128/mBio.00931-14
  83. Zhang Y, Mooney RA, Grass JA, Sivaramakrishnan P, Herman C, Landick R, Wang JD. 2014. DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest. Mol Cell. 53, 766-778. https://doi.org/10.1016/j.molcel.2014.02.005
  84. Kolb KE, Hein PP, Landick R. 2014. Antisense oligonucleotide-stimulated transcriptional pausing reveals RNA exit channel specificity of RNA polymerase and mechanistic contributions of NusA and RfaH. J Biol Chem. 289, 1151-1163. https://doi.org/10.1074/jbc.M113.521393
  85. Nayak D, Voss M, Windgassen T, Mooney RA, Landick R. 2013. Cys-pair reporters detect a constrained trigger loop in a paused RNA polymerase. Mol Cell. 50, 882-893. https://doi.org/10.1016/j.molcel.2013.05.015
  86. Mooney RA, Landick R. 2013. Building a better stop sign: understanding the signals that terminate transcription. Nat Methods. 10, 618-619. https://doi.org/10.1038/nmeth.2527
  87. Weixlbaumer A, Leon K, Landick R, Darst SA. 2013. Structural basis of transcriptional pausing in bacteria. Cell. 152, 431-441. https://doi.org/10.1016/j.cell.2012.12.020
  88. Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA. 2013. Structure and function of CarD, an essential mycobacterial transcription factor. Proc Natl Acad Sci U S A. 110, 12619-12624. https://doi.org/10.1073/pnas.1308270110
  89. Chung D, Park D, Myers K, Grass JA, Kiley P, Landick R, Keles S. 2013. dPeak: high resolution identification of transcription factor binding sites from PET and SET ChIP-seq data. PLoS Comput Biol. 9, e1003246. https://doi.org/10.1371/journal.pcbi.1003246
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  197. Lee DN, Phung L, Stewart J, Landick R. 1990. Transcription pausing by Escherichia coli RNA polymerase is modulated by downstream DNA sequences. J Biol Chem. 265, 15145-15153. http://www.jbc.org/content/265/25/15145
  198. Adams MD, Wagner LM, Graddis TM, Landick R, Antonucci TK, Gibson AL, Oxender DL. 1990. Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli. J Biol Chem. 265, 11436-11443. http://www.jbc.org/content/265/20/11436
  199. Landick R, Colwell A, Stewart J. 1990. Insertional mutagenesis of a plasmid-borne Escherichia coli rpoB gene reveals alterations that inhibit beta-subunit assembly into RNA polymerase. J Bacteriol. 172, 2844-2854. https://doi.org/10.1128/jb.172.6.2844-2854.1990
  200. Chan C, Landick R. 1989. The S. typhimurium his operon leader region contains an RNA hairpin-dependent transcription pause site: mechanistic implications of the effect on pausing of altered RNA hairpins. J Biol Chem. 264, 20796-20804. http://www.jbc.org/content/264/34/20796
  201. Ti-zhi S, Copeland BR, Landick R, Graddis JT, Oxender DL. 1988. Export of hybrid proteins of leucine-specific binding protein and trypotophan synthetase in Escherichia coli. Acta Biochim Biophys Sinica. 20, 364-370.
  202. Landick RC. 1987. The role of the paused transcription complex in trp operon attenuation. In RNA polymerase and the Regulation of Transcription. A Steenbock Symposium (Reznikoff WS, Burgess RR, Dahlberg JE, Gross CA, Record MT Jr, Wickens MP, eds.), pp. 441-444, Elsevier, New York.
  203. Landick R, Yanofsky C. 1987. Transcription attenuation. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt FC, Ingraham JL, Low KR, Magasanik B, Schaechter M, Umbarger HE, eds.), pp. 1276-1301, American Society for Microbiology, Washington, D.C.
  204. Landick R, Yanofsky C. 1987. Isolation and structural analysis of the Escherichia coli trp leader paused transcription complex. J Mol Biol. 196, 363-377. https://doi.org/10.1016/0022-2836(87)90697-8
  205. Landick R, Carey J, Yanofsky C. 1987. Detection of transcription-pausing in vivo in the trp operon leader region. Proc Natl Acad Sci U S A. 84, 1507-1511. https://doi.org/10.1073/pnas.84.6.1507
  206. Nazos PM, Antonucci TK, Landick R, Oxender DL. 1986. Cloning and characterization of livH, the structural gene encoding a membrane component of the leucine transport system in Escherichia coli. J Bacteriol. 166, 565-573. https://doi.org/10.1128/jb.166.2.565-573.1986
  207. Stewart V, Landick R, Yanofsky C. 1986. Rho-dependent transcription termination in the tryptophanase operon leader region of Escherichia coli K-12.  J Bacteriol. 166, 217-233. https://doi.org/10.1128/jb.166.1.217-223.1986
  208. Landick R, Oxender DL, Ames GFL. 1985. Bacterial amino acid transport systems. In The Enzymes of Biological Membranes, 2nd Edition, Vol. 3 (Martonosi A, ed.), pp. 577-615, Plenum Press, New York.
  209. Antonucci TK, Landick R, Oxender DL. 1985. The leucine binding proteins of Escherichia coli as models for studying the relationships between protein structure and function. J. Cell. Biochem. 29, 209-216. https://doi.org/10.1002/jcb.240290305
  210. Landick R, Carey J, Yanofsky C. 1985. Translation activates the paused transcription complex and restores transcription of the trp operon leader region. Proc Natl Acad Sci U S A. 82, 4663-4667. https://doi.org/10.1073/pnas.82.14.4663
  211. Landick R, Oxender DL. 1985. The complete nucleotide sequences of the E. coli LIV-BP and LS-BP genes: implications for the mechanism of the LIV-I transport system. J Biol Chem. 260, 8257-8261. http://www.jbc.org/content/260/14/8257
  212. Landick R. 1984. Regulation of LIV-I transport system gene expression. In Microbiology 1984 (L. Leive and D. Schlessinger, eds.), pp. 71-74, American Society for Microbiology, Washington, D.C.
  213. Oxender DL, Landick R, Nazos P, Copeland BR. 1984. The role of membrane potential in protein folding and secretion in Escherichia coli. In Microbiology 1984 (Leive L, Schlessinger D, eds.), pp. 4-7, American Society for Microbiology, Washington, D.C.
  214. Nazos PM, Su TZ, Landick R, Oxender DL. 1984. Branched-chain amino acid transport in Escherichia coli. In Microbiology 1984 (Leive L, Schlessinger D, eds.) pp. 24-28, American Society for Microbiology, Washington, D.C.
  215. Copeland BR, Landick R, Nazos PM, Oxender DL. 1984. Role of membrane potential in protein folding and domain formation during secretion in Escherichia coli. In Protein Transport and Secretion (Oxender D, ed.), pp. 279-290, Alan Liss Inc., New York.
  216. Landick R, Duncan JR, Copeland BR, Nazos PM, Oxender DL. 1984. Secretion and degradation of mutant leucine-specific binding protein molecules containing C-terminal deletions. In Protein Transport and Secretion (Oxender D, ed.), pp. 265-278, Alan Liss Inc., New York.
  217. Landick R, Maguire D, Lutter LC. 1984. Optimization of polyacrylamide gel electrophoresis conditions used for sequencing mixed oligodeoxyribonucleotides. DNA. 3, 414-419. https://doi.org/10.1089/dna.1984.3.413
  218. Landick R, Vaughn V, Lau ET, VanBogelen RA, Erickson JW, Neidhardt FC. 1984. Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein may be a transcription factor. Cell. 38, 175-182. http://doi.org/10.1016/0092-8674(84)90538-5
  219. Landick R, Yanofsky C. 1984. Stability of an RNA secondary structure affects in vitro transcription pausing in the trp operon leader region. J Biol Chem. 259, 11550-11555. http://www.jbc.org/content/259/18/11550
  220. Copeland BR, Landick R, Nazos PM, Oxender DL. 1984. Role of membrane potential in protein folding and domain formation during secretion in Escherichia coli. J Cell Biochem. 24, 345-356. https://doi.org/10.1002/jcb.240240405
  221. Landick R, Duncan JR, Copeland BR, Nazos PM, Oxender DL. 1984. Secretion and degradation of mutant leucine-specific binding protein molecules containing C-terminal deletions. J Cell Biochem. 24, 331-344. http://doi.org/10.1002/jcb.240240404
  222. Landick R, Daniels CJ, Oxender DL. 1983. Influence of membrane potential on the insertion and transport of proteins in bacterial membranes. In Methods in Enzymology, Vol. 97, Biomembranes, Part K, Membrane Biogenesis: Assembly and Targeting (Prokaryotes, Mitochondria, and Chloroplasts) (Fleischer S, Fleischer B, eds.), pp. 146-153, Academic Press, New York.
  223. Daniels CJ, Anderson JJ, Landick R, Oxender DL. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins. J Supramol Struct. 14, 305-311. https://doi.org/10.1002/jss.400140305
  224. Landick R, Anderson JJ, Mayo MM, Gunsalus RP, Mavromara P, Daniels CJ, Oxender DL. 1981. Regulation of the high-affinity leucine transport genes of Escherichia coli. J Supramol Struct. 14, 527-537. https://doi.org/10.1002/jss.400140410
  225. Landick R, Oxender DL. 1982. Bacterial periplasmic binding proteins. In Membranes and Transport: A Critical Review, Vol. 2 (Martonosi A, ed.), pp. 81-91, Plenum Press, New York.
  226. Landick R, Anderson JJ, Mayo MM, Gunsalus RP, Mavromara P, Daniels CJ, Oxender DL. 1981. Regulation of the high-affinity leucine transport genes of Escherichia coli. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (Blume A, Diamond I, Oxender D, Fox CF, eds.), pp. 343-353, Alan Liss Inc., New York.
  227. Daniels CJ, Anderson JJ, Landick R, Oxender DL. 1981. The in vitro synthesis and processing of the branched-chain amino acid binding proteins. In Progress in Clinical and Biochemical Research, Membrane Transport, and Neuroreceptors (Blume A, Diamond I, Oxender D, Fox CF, eds.), pp. 319-325, Alan Liss Inc., New York. [PDF]
  228. Oxender DL, Anderson JJ, Daniels CJ, Landick R, Gunsalus RP, Zurawski G, Yanofsky C. 1980. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and mature form. Proc Natl Acad Sci U S A. 77, 2005-2009. https://doi.org/10.1073/pnas.77.4.2005 [PDF]
  229. Oxender DL, Anderson JJ, Daniels CJ, Landick R, Gunsalus RP, Zurawski G, Selker E, Yanofsky C. 1980. Structural and functional analysis of cloned DNA containing genes responsible for branched-chain amino acid transport in Escherichia coli. Proc Natl Acad Sci U S A. 77, 1412-1416. https://doi.org/10.1073/pnas.77.3.1412 [PDF]
  230. Marino JP, Landick RC. 1975. 1-Phenylthiocyclopropyl-triphenylphosphonium fluoborate: a new synthon for cyclopentanone synthesis. Tetrahedron Lett. 51, 4531-4534. https://doi.org/10.1016/S0040-4039(00)91063-3 [PDF]